To evaluate the effectiveness and safety of Shenfu Injection used in perioperative period.Methods:Four electronic literature databases including CNKI，Wanfang Data，VIP，and SinoMed were searched to identify eligible randomized clinical trials on ShenFu used for perioperative period，and some relevant Chinese journals were also hand-searched for potentially eligible clinical studies.The quality of included studies was assessed against entries of the risk of bias table as recommended in the Cochrane handbook，and the data was analyzed using RevMan.Results:A total amount of eighteen studies involving 1 324 patients met the inclusion criteria for this review，and the quality of these studies were C level.Meta-analysis showed following Results:Shenfu injection combined with routine Western medicine has better effect on perioperative period in maintaining the stability of circulation（SBP［WMD =-18.74，95%CI（-21.26，-16.23），P<0.000 01］，DBP［WMD =-8.41，95%CI（-10.44，-6.37）P<0.000 01，HR［WMD =-10.59，95%CI（-12.50，-8.68），P<0.000 01］），elevating β-endorphin［WMD =28.93，95%CI（22.13，35.73），P<0.000 01］，promoting anesthesia wake-up including shortening the time of extubation［WMD =-9.62，95%CI（-11.61，-7.64），P<0.000 01］and leaving the ICU［WMD =-17.06，95%CI（-22.06，-12.06），P<0.000 01］），promoting the recovery after operation including shortening the time of extubation［WMD =-2.77，95%CI（-3.02，-2.53），P<0.000 01］and leaving the ICU［WMD =-11.26，95%CI（-15.17，-7.35），P<0.000 01］）.There was statistically significant difference compared with the pure western medicine treatment.Conclusion:Shenfu injection plays a protective role in the perioperative period，which can be against the perioperative adverse stimuli by maintaining the stability of circulation，and promote the recovery after operation.It is better than the pure western medicine treatment.This conclusion still needs more high quality clinical trials to further verify.