The study was to explore the effect of TCM abdominal vibration treatment on glucagon -like peptide -1 (GLP-1) and rats glucose metabolism. Methods:To induced animal models of type 2 diabetes with Long-term high glucose and lipid diet and a small dose of streptozotocin (STZ， 30mg·kg-1， ip). Rats were randomly divided into control group， model group， western medicine group， abdominal vibration group， western medicine plus abdominal vibration group. Results:After treatment， the weight of abdominal vibration group was significantly reduced compared to T2DM model group. Weight reduction was more significant in western medicine plus abdominal vibration group than in western medicine group (P<0.05). GLP-1 increased significantly in abdominal vibration group， western medicine group， western plus abdominal vibration group (P<0.05). The pathological slice of Islet beta cell showed that western medicine plus abdominal vibration group was least damaged， followed by abdominal vibration group， western medicine group and model group. Conclusion:Abdominal vibration therapy can reduce serum glucose， relieve diabetes symptoms and cell damage via GLP-1 pathway.