To explore the effect of the Mongolian warm acupuncture on VEGF levels in brain tissue， infarct volume， brain water content in rats with cerebral ischemia after reperfusion. Methods: Male SD rats were randomly divided into Mongolian warm acupuncture group， acupuncture group， nimodipine group， sham operation group， and model group. Modified suture method was used to set up artery occlusion in rats occlusion and reperfusion model. Rats in each group except sham group and model group were treated for one hour once a day after being successfully modelled. The nerve function， VEGF levels in brain tissue， infarct volume and brain water content after 24 hours of surgery were measured. Results: The sham operation group had no nerve functional defect symptoms， and Mongolian warm acupuncture group showed significantly different outcomes in VEGF levels in the brain tissue compared with other groups; infarct volume and brain water content in each group were significantly different from those of the sham operation group， and Mongolian warm acupuncture group had significant differences in terms of infarct volume and brain water content compared with the model group. Conclusion: Mongolian warm acupuncture can improve rat neurological function after focal cerebral infarction and ease cerebral edema and reduce infarct volume effect. Mongolian warm acupuncture has very important clinical significance to treat ischemic stroke early intervention.