To optimize the extraction technology of total dioscin from Helleborus thibetanus Franch of Shaanxi by central composite design response surface method.Methods:Ethanol was used as the extraction solvent，and the parameters of ex-traction technology of total dioscin from Helleborus thibetanus Franch were optimized by 3 factors and 5 levels.Independent variables were ethanol concentration，ethanol multiples and extraction time; dependent variable was the dioscin content.Results:The optimal extraction technology was realized by the following conditions：ethanol concentration was 70%，ethanol was multiplied with 6.5 times，and extraction time was 2 hours.The maximal yield of total dioscin reached to 0.065 8 g/g.Regression coefficient of the binomial fittingcomplex model was 0.8 475.Conclusion:The technology can be used as the extraction process of total dioscin from Helleborus thibetanus Franch of Shaanxi.