HuangQi Decoction, also called HuangQiLiuYi Decoction, which is made by HuangQi and GanCao were first documented in the Taiping Huimin Heji Ju Fang. It is a prescription that can treat any kind of asthenic disease, whose symptoms include limb weakness, dysphoria and palptation, dry lips, thirst, poor appetite and yellowish complexion. HuangQi, together with GanCao and DaZao, plays a major role in this decoction to tonifying Qi and deficiency, and it has been widely used in the form of unilateral or compound. With the functions of replenishing Qi, strengthening essence and reinforcing deficency, HuangQi Decoction can improve hepatocytic apoptosis in liver cirrhosis caused by chronic hepatitis B, enhance hepatocyte function and promote the reverse of hepatic histology according to the previous work of our research group. This paper focuses on the research of chronic liver disease treated by HuangQi Decoction.