The purpose of this study is to investigate the mechanism of Fuzheng Huayu Components formula against Liver Fibrosis relating to Angiogenesis. Methods： Using DMN-induced liver fibrosis model in mice,Fuzheng Huayu formula as positive control. Liver fibrosis was estimated by Sirius red staining and hydroxyproline content assay. Liver angiogenesis was evaluated by liver tissue microvascular imaging analysis and MVD labeled by CD31. VEGF-R2 expression was observed by western blot. Zebrafish functional intersegmental vessels count and alkaline phosphatase activity was to investigate angiogenesis. Results： Fuzheng Huayu Components formula can alleviate liver function in DMN mice (P<0.01).Liver collagen deposition and hydroxyproline content were reduced significantly (P<0.01). The hepatic microvasculature reduced(P<0.01) with the VEGFR2 protein expression down regulated accordingly(P<0.01). It also inhibited alkaline phosphatase activity in zebrafish. Conclusion： Fuzheng Huayu Components formula inhibited liver fibrosis in DMN-treated mice. Its mechanism may be related to inhibit angiogenesis.