To observe the curative effects of Ziguizhangpi Ointment(ZG） combined with silver alginate in the treatment of unhealed wounds after breast cancer operation and explore the mechanism.Methods：Eighty patients were randomly divided into control group and treatment group (n=40). Patients in control group were treated by silver alginate, while patients in treatment group were treated by ZG combined with silver alginate. After 6 weeks of treatment, the clinical effects, on wound healing, and expression of vascular endothelial growth factor (VEGF) were evaluated.Results：In the control group, the curative rate and total effective rate were 68.42% and 81.58%, and they were 86.49% and 94.59% respectively in treatment group (P<0.05); Immunohistochemistry showed that VEGF expression in control group was（1117.95±373.54）μm2,and it was（1447.64±240.18）μm2 in treatment group(P<0. 01).Conclusion：Combined application of ZG and silver alginate can improve wound healing rate and upregulate the expression of VEGF. It shows no noticeable adverse effect, therefore it is worth of clinical application.