To investigate the effect of matrine injection combined with ibandronate clinical observation on treatment of non small cell lung cancer pain of bone metastasis.Methods： 98 patients with non small cell lung cancer bone metastasis were recruited from 2010 March to 2012 March.According to their different ways of treatment,they were divided into control group and observation group.The control group was treated with ibandronate treatment,the observation group were treated by compound matrine injection combined with ibandronate treatment.Efficacy,remission,and KPS score improvement were compared.Results： The near future curative effect in the results show that the partial remission cases (%) and the total effective rate of the observation group was obviously superior to the control group,and the difference was statistically significant (P<0.05).Karnofsky score improvement cases (%) of the observation group is higher than that of the control group,and the difference was statistically significant (P<0.05).Pain relief comparative analysis showed that complete remission cases (%) and the total remission rate of the observation group was significantly superior to the control group,and the difference was statistically significant (P<0.05).The incidence of adverse reactions had no significant difference between the two groups (P>0.05).Conclusion： Compound matrine injection combined with ibandronate is significant in treating cancer pain in non small cell lung cancer bone,and can effectively reduce the pain of patients,thus is worthy of clinical application.