To observe clinical effects of self-made kidney tonifying decoction on urinary albumin in patients with early Diabetic Nephropathy and to explore its partial mechanism.Methods： Sixty patients with type 2 diabetic nephropathy admitted at our hospital were randomly divided into control group (n=30) and observation group (n=30),and patients in both groups were given health education,diet instruction,internal medicine hypoglycemic therapy,80 mg/day of conventional oral valsartan.Those who also had hyperlipidemia were given extra treatment of simvastatin,20 mg/day.Observation group also applied the self-made kidney tonifying decoction based on the conventional treatment,200 ml water tisanes,1 agent daily in the morning and evening,for 12 continuous weeks.After a period of treatment,24h microal buminuria quantitative determination,glycosylated hemoglobin (HbAlc),fasting blood-glucose (FGC),2 h postprandial blood glucose (2 HBG) changes of patients of the two groups before and after treatment were recorded; and protein expression level changes of serum PI3K,Akt,p - Akt,bad,p - bad,Bcl 2,Bax and Caspase 3 were measured.Results： 1) The levels of 24h microalbuminuria quantitative determination,FPG,OGTT after treatment were reduced compared to those before treatment in both groups,and the reduction extent of observation group were more obvious compared with those of the control group (P<0.05); 2) the levels of serum PI3K,p-Akt,p-bad,the Bcl-2 protein expression in the two groups after treatment were increased compared to those before treatment,and the Bax,Caspase 3 protein expression was reduced,the change magnitude of observation group were more obvious compared with those of the control group (P<0.05).Conclusion： Self-made kidney tonifying decoction has obvious effect to reduce proteinuria of diabetic nephropathy,and its mechanism may be associated with PI3K/Akt signal transduction pathway.