The author analyzed professor Li Dexins clinical experience on differentiation treatment. Professor Li Dexins diagnostic and therapeutic features were summarized as follows： 1) Clarifing the nature of the disease and emphasize syndrome differentiation; 2) The drugs shall target precisely while the prescription shall be refined; 3)Paying attention to processing China materia medician, at the same time be attenuated and enhance curative effect; 4)The disease treatment shall be based on the spleen and stomach; 5)The doctor shall be profound on traditional Chinese medicine and often paying attention to examination of tongue and pulse. It was hoped that the fellow shall get inspiration from the paper.