To clarify the mechanism of Shenkangling on mesangial cells and to observe oxidized low density lipoprotein(ox-LDL) induced Mesangial Cells(MCs) secretion of inflammatory cytokine.Methods：MCs were treated with Shenkangling,and the levels of the inflammatory cytokines,such as CXCL16,CD36,IFN-γ,IL6,TNF-αby ELISA,Real Time-PCR and Western blot were detected.Results：The levels of CXCL16,CD36,IFN-γ,IL6,TNF-α were significantly increased after CXCR6 joined and ox-LDL induced mesangial cell proliferation,then all levels were significantly reduced by Shenkangling in a concentration dependent manner.Conclusion：ox-LDL may promote the release of inflammatory mediators such as in mesangial cells,and CXCR6 may mediate this path.Shenkangling has effects for ameliorating ox-LDL-induced MC proliferation and inflammatory reactions.