To explore the antidepressant effect of angelica sinensis in treatment of depression.Through literature analysis and the clinical efficacy of angelica sinensis and its pathogenetic characteristics in treating depression,the paper summarized the rule of antidepressant effect of angelica sinensis.In the treatment of depression,angelica sinensis could not only enrich the blood to nourish the liver body,invigorate the circulation of blood to open the heart arteries and veins,but also relax the bowels.The compound prescription of antidepressant,in which the angelica sinensis plays an important role,is widely used in clinical.The role of angelica sinensis in depression demands the further study.