Excessive fat and emotional depression are basic causes of non-alcoholic fatty liver disease. Pathogenic locations of the disease are live and spleen; the pathogenesis of the disease is liver stagnation and spleen deficiency; and the symptoms usually refer to sputum / turbidity, dampness, blood stasis. Treatment of the disease mainly depends on regulating liver and spleen. Based on the experiences of more than 20 famous TCM doctors, this article analyzed their treatment strategies and medication rules of treating nonalcoholic fatty liver disease with method of regulating liver and spleen.