Chronic atrophic gastritis (CAG) as a common gastrointestinal disease has higher prevalence and a certain tendency to canceration. To date, general-accepted effective therapy remains absent. Characteristics and advantages of Chinese medicine treatment in this disease have gradually been recognized. Regulating liver and spleen is one of methods in TCM, which is applied to treat CAG through coordinating the function of liver and spleen as well as compatibility of the effects.