To explore the efficacy and safety of intermittent drug intake on treating chronic pelvic inflammatory disease due to damp heat and blood stasis; and provide a new method for the clinical treatment of chronic disease, which has a better drug safety and less side effects; and also was to help patients receive a more convenient and economical treatment. Methods: A total of 72 cases of chronic pelvic inflammatory disease were randomly divided into a treatment group (36 cases) and a control group (36 cases) and both groups received silver vine mixture treatment. The treatment group received intermittent medication treatment and the control group received traditional medication treatment for 8 weeks. Results: The markedly effective rate of the treatment group was 88.89% and the control group was 86.11%. There was no significant statistical difference (P>0.05) between the two groups. Comparing with the control group, the treatment group showed less gastrointestinal side effects. Conclusion: Intermittent medication and the traditional medication have a similar efficacy, while intermittent medication method may decrease patients’ economic burden and reduce the side effects, so could be applied to clinical treatment.