The pathogenesis of diabetes, which refers how the risk factors develop complications, could be summarized as liver, spleen and kidney deficiency. This theory is an effective theoretical model in TCM. According to this theory, prescriptions which are represented by Shenqi Wan, could adjust overall metabolism and restoring blood sugar balancing in treating prediabetes. Combined with low-dose insulin secretion drugs, the prescriptions could be applied effectively to control blood glucose level of patients with mild diabetes and glucose excursions. In clinical practicing, the prescriptions can be modified according to the pathological characteristics such as Qi deficiency, Yin deficiency, heat, phlegm, and blood stasis.