To explore the traditional treatment rules of refractory urinary tract infections through data mining. Methods: We collected as much literature on refractory urinary tract infections as we can via China Knowledge Resource Integrated Database (KNS). Through noise suppression and data slicing algorithm based on sensitive keywords frequency, we summarized the disease etiology, pathogenesis, site of infection, tongue manifestation, symptom, syndrome, treatment methods, TCM formula, visualize the treatment rule in one dimensional level and in two-dimensional network diagram.Results:The TCM etiology and pathogenesis of refractory urinary tract infections concerns vital qi deficiency when pathogenic qi is prevailing. Kidney deficiency and bladder damp-heat was the main pathogenesis. Treatment methods include tonifying kidney, cleaning heat and dispelling damp. The results is well consistent with our clinical practice.Conclusion:With data mining, we systematically reviewed the literatures and prescriptions of refractory urinary tract infections and make objective summary of the rules of treatment.