To observe the curative effect of Guyuan Xingnao Decoction combined with oxiracetam in patients with MCI. Methods: Sixty patients with MCI were randomly divided into two groups. The observation group was given Guyuan Xingnao Decoction and oxiracetam, and the control group was solely given oxiracetam. MMSE, MoCA, ADL were employed to assess the levels of Aβ and IL-6. Treatment duration lasted for three weeks. Results: After treatment, the MMSE, MoCA scale score and levels of Aβ and IL-6 were all better than those of the control group, and the results is of statistical difference (P<0.05). Compared with before, MMSE, MoCA, ADL scale score and Aβ, IL-6 of both groups were lower (P<0.05). Besides, the treatment group reduction degree of scores were larger than those of the control group (P<0.05). Conclusion: Guyuan Xingnao Decoction combined with oxiracetam can significantly decrease the Aβ and IL-6 levels in patients with MIC and improve their cognitive function.