To compare the efficacy of YiQiHuoXue herbal extracta (treatment group) with BuYang HanWu granules (control group) by blood coagulation index.Methods:This prospective randomized controlled study enrolled 30 Qi Deficiency and Blood Stasis Syndrome(QDBSS) patients in the treatment group which was treated with agreement herbal extract, and enrolled 30 QDBSS patients in the control group which was treated with BuYang HanWu granules. Used blood coagulation index to assess efficacy of two group in 28th day.Results:After treating with YiQiHuoXue herbal extracta, PT, APTT and TT prolonged, while FIB decreased. And the blood coagulation indexes of treatment group improved dramatically than control group (P<0.05).Conclusion:To compare with control group, YiQiHuoXue herbal extract had better effects on improving blood coagulation index. YiQiHuoXue herbal extracta is safe to use in clinical practice.