To investigate the effect of Ningxin Anshen prescription combined with acupuncture and massage on the sleep quality of insomnia patients, serving to provide reference for the treatment of insomnia.Methods:Insomnia patients treated in our hospital from April 2010 to June 2012 who met the inclusion criteria were selected as study objects. Patients were randomly divided into three groups, traditional Chinese Medicine (TCM) Group, Acupuncture Group, Combination Group. Patients in the TCM group were treated with Ningxin Anshen prescription once a day. Patients in acupuncture group received acupuncture on Sishencong, Yintang, Anmian, Taiyang; one treatment every three days, and four times per course of treatment. The Combination Group applied Ningxin Anshen prescription combined with acupuncture in Sishencong, Yintang, Anmian, Taiyang, and treatment method was the same with TCM group and acupuncture group. Two courses of treatment were given with treatment interval of three days. Before and after treatment, Pittsburgh Sleep Quality Index (PSQI) was evaluated.Results:The effective rate of combination group was 100%, which was significantly higher than that of the TCM group and acupuncture group (by rank sum test, the three groups, χ2=7.493,P=0.024<0.05); comparing combination group and acupuncture group,Z＝-2.579,P=0.009<0.05, and the difference was statistically significant, indicating that the combination group was better than the acupuncture group; the PSQI score before treatment was with no significant difference,P>0.05; after treatment, sleep time, sleep time, sleep efficiency, sleep temporarily hinder, daytime function, scores, analysis of variance,P<0.05, illustrating the three groups PSQI score, there were significant differences; the combination group and TCM group,P<0.05; combination group and acupuncture group,P<0.05; TCM group and acupuncture group,P>0.05. After treatment, PSQI score of combination group was better than TCM group and the acupuncture group.Conclusion:Ningxin Anshen prescription and acupuncture can both significantly improve patients sleep, but the combination of the two is superior.