To discuss the clinical curative effect and part of its mechanism of modified Juantong decoction for the treatment of endometriosis dysmenorrhea.Methods:Fifty cases of patients with endometriosis dysmenorrhea treated in our hospital during April 2011 to November 2013 were included in the study and divided into observation group and control group according to admission order, with 25 cases in each group. Patients in control group received oral gestrinone from the first day of their menstruation, 2 times per week, 2.5 mg/time, continuously for 12 weeks. The observation group had warm modified Juantong decoction apart from the same treatment as the control group, though from the second day after the menstruation ends, 2 times/day, 100 mL per time, continuously for 12 weeks. No other drugs were applied during treatment in both groups. hepatic and renal function, degree of dysmenorrhea score, endometrial antibody (EmAb) concentration of endometrial of the two groups of the patients after the treatment were observed.Results:1) after the drug intervention, dysmenorrhea score decreased, the decrease of observation group was more obvious (P<0.05); 2) through Western blotting and Elisa detection of EmAb level, it was found that endometrial EmAb level decreased in both of the two groups of patients, the down trend of EmAb serum concentration in the observation group was more significant than the control group (P<0.05); 3) both groups had no hepatic and renal function lesion.Conclusion:The increase of EmAb can induce endometriosis dysmenorrhea, and modified Juantong decoction can reduce EmAb concentration to treat endometriosis dysmenorrhea.