To investigate the intervention effect of Salvianolic acid A, B and their component molecules of drug compatibility on expression of CTGF and Par-3 in the process of renal fibrosis. Methods: A total of 50 male Sprague-Dawley rats were randomly divided into five groups: normal group (n=10), the control group (n=10), salvianolic acid A group (n=10), salvianolic acid B group (n=10) and salvianolic acid A and B group (n=10). All rats were made into unilateral ureteral obstruction (UUO) model except the normal group. After two weeks of treatment, we took blood sample from abdominal aorta and examined Cr and BUN levels; and observed CTGF, Par-3 protein expression in kidney tissue by immunofluorescence. Results: 1)Results of renal function test: model groups serum Cr level was significantly higher than the normal group (P<0.05); the Sal A groups serum Cr level was obviously lower than the model group (P<0.05); the serum BUN levels in the Sal group A and group B significantly lower than the model group; among the treatment groups, serum Cr and BUN levels showed no significant difference (P> 0.05). 2)Results of CTGF immunofluorescence test: the number of rat renal tubular epithelial cells showing positive in model group significantly increased compared to the control group and the fluorescence intensity significantly enhanced (+++); after treatment of Sal A, B, and component compatibility, CTGF fluorescence intensity was reduced compared with the model group , among which the Sal A+B group decreased significantly (±) and followed by the Sal B group (+). 3)Results of Par-3 immunofluorescence test: the number of positive cells in rat renal tubular epithelial cells in the model group was significantly decreased than the normal group and the fluorescence intensity was significantly reduced (±); after treatment of Sal A, B and component compatibility, Par-3 the fluorescence intensity in the Sal A, Sal B, Sal A+B group was significantly enhanced compared with the model group , among which the Sal A+B group enhanced most obviously (+++), and followed by the Sal group B (++). Conclusion: Sal A, B and component compatibility treatment could partly improve rats renal function, but showed no significant difference. The Sal A+B group could significantly inhibit the expression of CTGF in renal tissue and promote expression of Par-3, and its effect was better than the Sal A group and Sal B group. It may be related to promoting the expression of Par-3 and reducing the expression of CTGF in UUO kidney tissue of rats.