To analyze the medication rules of prescriptions for hyperlipidemia.Methods: Based on the database built by the prescriptions for hyperlipidemia,the methods of association rules with apriori algorithm and complex system entropy cluster were used to achieve the frequency of medicines,association rules between drugs and others.Results: The data-mining results indicated that the highest frequency used Chinese medicine were Alismatis Rhizoma,Crataegi Fructus,Salviae Miltiorrhizae Radix et Rhizoma,Cassiae Semen,and Poria.The most frequent drug combinations were “Crataegi Fructus,Alismatis Rhizoma”,“Crataegi Fructus,Salviae Miltiorrhizae Radix et Rhizoma”,and “Salviae Miltiorrhizae Radix et Rhizoma,Alismatis Rhizoma”.The drugs with a high degree confidence coefficient of association rules included “Polygoni Multiflori Radix -> Crataegi Fructus”,“Salviae Miltiorrhizae Radix et Rhizoma,Polygoni Multiflori Radix -> Crataegi Fructus”,and “Polygoni Multiflori Radix,Alismatis Rhizoma -> Crataegi Fructus”.The new prescriptions included “Aurantii Fructus,Corydalis Rhizoma,Trichosanthis Pericarpium,Citri Reticulatae Pericarpium Viride”,and “Rehmanniae Radix Praeparata,Cassiae Semen,Dioscoreae Rhizoma,Polygoni Multiflori Radix,Rhei Radix et Rhizoma”.Conclusion: The Chinese medicine applied in the prescriptions for hyperlipidemia mostly have the effects of invigorating the spleen,eliminating dampness,reducing phlegm,promoting blood circulation by removing blood stasis and clearing heat,which reflects the principles of synchronically treating phlegm and blood stasis,giving consideration to both the incidental and fundamental.