To investigate the distribution of TCM Syndromes of anxiety and depression in myocardial infarction after PCI. Methods: A total of 438 patients with myocardial infarction were assessed by Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS). The information of patients were collected and then statistically analyzed by SPSS15.0. Results: Among 438 recruited patients, 107 (24.4%) had anxiety with or without depression. The distribution of TCM syndromes of myocardial infarction with anxiety and depression was as follows: blood stasis (84 cases, 78.5%), Qi deficiency (69 cases, 64.49%), Yin deficiency (51 cases, 47.66%), phlegm (43 cases, 40.19%), Qi stagnation (38 cases, 35.51%), Yang deficiency (27 cases, 25.23%), Cold coagulation(14 cases, 13.08%). The syndrome of Qi stagnation was more common seen in myocardial infarction with anxiety and depression than patients without such syndromes (P＝0.002). TCM symptom score and stuffiness chest score were higher in patients with anxiety or depression than the others. Conclusion: Stasis syndrome is the main syndrome of myocardial infarction with or without anxiety and depression. The syndrome of Qi stagnation was an obvious syndrome of patients with anxiety and depression.