To explore the impact of schisandra chinensis on the expression of IL-8 and VEGF in gastric Ulcer rats model induced by glacial acetic acid combined with cold or heat syndrome.Methods:Exposing the rats in cold or heat environment and applying glacial acetic acid to skin to establish gastric ulcer model combined with cold and heat syndrome. Using HE stain to observe the pathologic changes, using ELISA, RTPCR as well as Immunohistochemistry to detect the contents of IL-8 or VEGF both in serum and in stomach. Results:Schisandra chinensis diminishes the area of ulcer. Compared with the blank group, the contents of both IL-8 and VEGF increased remarkably in each ulcer model group without schisandra chinensis. (P<0.01). Schisandra chinensis can up-regulate the expression of VEGF while down-regulate the expression of IL-8 in both serum and stomach of heat-ulcer group or cold-ulcer group obviously ( P<0.05).Conclusion:The therapeutic action of Schisandra chinensis on heat-gastric ulcer or cold-gastric ulcer can be achieved by up-regulating the expression of VEGF while down-regulating the expression of IL-8 in both serum and stomach.