To explore the effects of the various diagnosis and treatment of acupuncture and moxibustion mode on the meridian status of patients with climacteric syndrome. Methods: One hundred and twenty five patients were randomly divided into treatment group of 63 cases and control group of 62 cases with the research method of randomized controlled blind evaluators. The treatment group was treated with Wang Juyi’s treatment mode of meridian examination methods; the other was used regular acupuncture and the situation of abnormal distribution of meridians of pre-therapy and post-treatment was observed. Results: Five of six meridians of both two groups of patients had a high percentage of abnormality except the Taiyang before the treatment especially Taiyin and Jueyin. The comparison of the two groups had no difference （P>0.05）. The number of abnormal meridians of treatment group patients was progressively reduced after treatment; however, there was no obvious change in the control group, but a gradual increasing trend. Statistical analysis of Taiyang, Shaoyang and Jueyin of the two groups showed statistical significance (P<0.05). The correlation analysis of meridians and symptoms revealed the Taiyang was related to waist pain and languor significantly, which had statistical significance. Hypomnesia, depression and dizziniess were significantly related to the Jueyin, which had statistical significance. Conclusion: Wang Juyi’s treatment mode of meridian examination method is superior to the regular acupuncture method in the improvement of abnormal meridians.