Multiple system disease is a pathological condition of old age when the functions of multiple systems, such as blood, liver, respiratory, digestive, urinary, endocrine, cardiovascular neurological, musculoskeletal are declined. Employing its unique methods——“Pattern Differentiation” to diagnose diseases and “Holism” to treat, Traditional Chinese Medicine(TCM) has great significance in tracking the occurrence and development of disease, developing the therapeutic methods and principles in treating chronic diseases and improving health care. This article initially explored the possibility of categorizing TCM patterns of elderly patients with multiple system diseases by multivariate statistical analysis methods in order to provide instructions for clinical treatment.