To explore and discuss the clinical efficacy and safety of the self-designed prescription, Qilian tablets, in treating chronic non-specific ulcerative colitis. Methods: A total of 143 patients with chronic non-specific ulcerative colitis, who are categorized under traditional Chinese medical theory as spleen-stomach qi deficiency and internal accumulation of dampness-heat were randomly divided into a treatment group(108 cases)and a control group(35 cases)at a ratio of 3:1. Treatment group had Qilian tablets and a prescription mimicking spleen and intestine invigorating pills. Control group utilized a prescription mocking the efficacy of Qilian tablets and a combination of spleen and intestine invigorating pills. Two groups received treatment for two months. Results: In the treatment group, while treating chronic non-specific ulcerative colitis, the treatment efficacy was listed with an obvious effective rate of 27.78%, a total effective rate of 85.19%. In the control group, the rate was 22.86% and 77.14% respectively. Among the treatment group under the internal accumulation of dampness-heat subcategory, the total obvious effective rate was 72.22%, the total effective rate was 94.44%; while the rate at the control group was at 51.43% and 88.57% accordingly. Comparison among groups presented with a difference which has statistical significance(P<0.05). Conclusion: Utilizing Qilian tablets in treating chronic non-specific ulcerative colitis showed satisfactory efficacy.