To observe the curative effect of vinpocetine combined with salvia ligustrazine in treating cerebral infarction and its influence on blood rheology.Methods:Two hundred and twelve cases of patients with cerebral infarction were randomly divided into control group and treatment group. Patients in the control group received oral atorvastatin and enteric coated aspirin and intravenous infusion of Danshen Ligustrazine Injection. Patients in the treatment group not only received the above treatment, but also were given 20 mg intravenous drip of vinpocetine injection; dynamic recorded before treatment and egional cerebral blood flow (rCBF) and electroencephalogram (EEG) on 5d, 10d, 15d, 21d after treatment. The levels of total cholesterol, low density lipoprotein cholesterol, ESR and blood platelet aggregation rate and fibrinogen activity, whole blood high shear viscosity, whole blood viscosity and bottom hematocrit and blood rheological index before and after the treatment, calculation of Stroke Scale (NIHSS) and Barthel index ADL were measured before and 3 weeks after treatment (W) in patients, and the total efficiency was calculated.Results:Vinpocetine combined with Danshen Ligustrazine could significantly reduce blood platelet aggregation rate and fibrinogen activity, whole blood high shear viscosity, whole blood viscosity increase bottom cut, rCBF and restore EEG to the normal state, the score of NIHSS decreased significantly, ADL was significantly improved, and the total effective rate was 97%, compared with the control group,P<0.05, there were significant significant differences.Conclusion:The therapeutic effect of vinpocetine combined with Danshen Ligustrazine on cerebral infarction is ideal.