To observe the effect of Danhong injection on blood coagulation function and blood lactic acid in patients with severe sepsis．Methods:A hundred patients with severe sepsis from the Intesive Care Unite were randomly classified into treatment group(n=52)and control group(n=48). Patients in both groups were treated with fluid resuscitation, anti infection drugs at admission and given the vasoactive drug, hydrocortisone and mechanical ventilation support when necessary. The treatment group was treated with Danhong injection intravenous infusion of 40 mL once a day. APACHE Ⅱscore, blood coagulation indexes and blood lactic acid were measured at admission and the seventh day of hospitalization. The mortality was monitored at the 28th day of hospitalization．Results: The blood coagulation indexes, blood lactic acid and APACHE Ⅱscore of the treatment group and the control group were of significant difference at the seventh day(P<0.05). The 28d mortality of the treatment group was lower than the control group, but the difference were not of statistically significance(P>0.05). Conclusion: Danhong injection can improve the blood coagulation state and decrease perfusion hypoxia in severe sepsis patients．