To investigate the effect and mechanism of traditional Chinese medicine Qingzhi granule on rats with alcoholic fatty liver.Methods:The composite molding method was used to induce alcoholic fatty liver rat model, and they were treated with traditional Chinese medicine Qingzhi granule intervention. The changes of liver histopathology and blood lipid, liver function, cytokine leptin Leptin and tumor necrosis factor alpha TNF- etc were observed.Conclusion:Traditional Chinese medicine Qingzhi granules can achieve the goal of the prevention and treatment of alcoholic fatty liver by improving blood lipid, liver function, and reducing serum TNF-α, Leptin level.