中药治疗高尿酸血症随机对照试验的系统评价
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Systematic Review of Randomized Controlled Trials of Chinese medicine in the Treatment of Hyperuricemia
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    摘要:

    目的:以循证医学系统评价为依据,对中药治疗高尿酸血症的临床疗效做出较客观的评估。方法:计算机检索国内医学期刊杂志(1980—2014年),选择中医药治疗高尿酸血症的随机对照试验研究进行Meta分析。结果:10篇文献进入Meta分析,总病例数为1000例。Meta分析显示与常规化学相比,中药组治疗高尿酸血症总有效率存在差异具有统计学意义(P=0.16,[OR=2.58,95%CI(1.58,4.21)]),降低血尿酸水平的Meta分析显示:[SMD=SMD=-0.58,95%CI(-0.90,-0.26),Z=3.53,(P=0.0004)],治疗组与对照组差异有统计学意义。结论:中医治疗组对高尿酸血症的总临床疗效及降低血尿酸水平方面与化学药对照组相比更优。本文受原始研究质量等因素的影响,研究结果存在一定局限性,期待开展更多大样本高质量的临床研究加以验证。

    Abstract:

    Using evidence-based medicine system to make an impersonal evaluation on the validity of Chinese medicine in the treatment of hyperuricemia. Methods: Randomized controlled trials(RCT) on Chinese medicines efficacy on treating hyperruricemia were retrieved from domestic medicinal journals (1980-2014) and then were evaluated through meta-analysis. Results: Ten studies involved 1000 patients were identified. The results showed that there was significant difference between using Chinese medicine and routine chemical to treat hyperruricemia: (P=0.16, [OR=2.58, 95%CI (1.58, 4.21)]). The meta-analysis result of reducing the level of blood uric acid was [SMD=SMD=-0.58, 95%CI(-0.90,-0.26), Z=3.53, (P=0.0004)]. The differences between treatment group and control group were of statistical significance. Conclusion: In both the aspects of total clinical efficacy and blood uric acid level reduction, the performance of treatment groups (using Chinese medicine) was better than the control groups (using chemical drugs). However, because some of the RCTs reviewed in this study did not fulfill the strict requirement of evidence-based medicine, the results of this study can have deviation. Therefore, more qualified research with large sample were expected to evaluate these results.

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霍晶晶,王丽,于世家.中药治疗高尿酸血症随机对照试验的系统评价[J].世界中医药,2015,10(08).

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  • 收稿日期:2014-12-26
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  • 在线发布日期: 2015-08-31
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