Semen non-liquefaction is an important reason that leads to infertility. Incomplete statistics shows that 70% of infertility patients have problem with abnormal semen liquefaction. There is not a particularly method to solve the problem currently, but TCM can explore the problem deeper. Semen non-liquefaction can be divided into syndrome of external pathogenic qi, syndrome of deficiency of kidney qi, syndrome of dampness-heat diffused downward, syndrome of intermingled phlegm and blood stasis, and syndrome of hyperactivity of fire due to yin deficiency during clinic observation. Basing the treatment on the basic principal of syndrome differentiation, TCM can be quite effective in disease differentiation. Numerous clinical observations suggest that it can achieve satisfactory results according to these five types of syndrome differentiation.