In 2014， American Association for the Study of Liver Disease(AASLD) and Europe Association for the Study of Liver(EASL) published Practice Guideline of Hepatic Encephalopathy in Chronic Liver Disease， which entails the diagnosis， treatment and prevention on minimal hepatic encephalopathy(MHE) and covert hepatic encephalopathy(CHE). This instructed on the integrated Chinese and Western medicines treatment on MHE. The guideline provides various suggestions on treatment course， curative effect， disease evaluation and endpoint of therapy according to different research， and point out the future focus on MHE and CHE. These can also assist in pushing the treatment of MHE using integrated Chinese and Western medicines.