To observe the effect of Total Glucosides of Peony (TGP) combined with Chinese medicine on elderly patients with Chronic Idiopathic Thrombocytopenic Purpura (CITP). Methods： Old patients with CITP of 63 cases were randomly divided into two groups： control group (33 cases)， treatment group (33 cases). The control group was given traditional treatment combined with Chinese medicine syndrome differentiation while the treatment group was given oral TGP (600 mg per time， 3 times per day) adding to the treatment of the control group. The therapeutic course was 3 months for the two groups. The platelet count level， the bleeding sites were observed before and after treatment as well as the clinical efficacy. Results： Firstly， the total effective rate of treatment group was 81.81% and 60.00% of control group， showing significant difference (P<0.05). Secondly， the platelet level， bleeding site， and effective time of the treatment group were all better than those of the control group with significant diffidence(P<0.05). Thirdly， the total effective rate showed significant diffierence within three syndromes in the treatment group (P<0.05)， syndrome of qi failing to control blood and renetic stirring of blood heat had better improvement than syndrome of yin deficiency and effulgent fire. Fourthly， there were eight patients having symptoms of diarrhea at the beginning of the treatment but recovered after treatment. Related indexes in western medicine showed no abnormalities. Original complications didn’t aggravate but even recovered. Conclusion： TGP combined with Chinese medicine can improve the level of peripheral blood platelet， shorten the onset time and effectively control bleeding symptoms with little adverse effect， especially for the syndrome of qi failing to control blood and renetic stirring of blood heat.