To investigate the effect of Tongxinluo with atorvastatin on blood lipids in patients with coronary heart disease.Methods：68 cases with coronary heart disease were selected and randomly divided into control group and observation group， 40 cases in each group. The patients in control group received conventional treatment， while patients in observation group added Tongxinluo and atorvastatin treatment. Lipid levels， lipid compliance rate and incidence of adverse reactions were compared before and after treatment.Results：The levels of serum lipids TC， TG， LDL-C， HDL-C， etc in two groups of patients before treatment were not statistically significant (P>0.05). 3 months after treatment， both groups TC， TG， LDL-C levels were lower than before treatment， HDL-C levels were higher than before treatment， and the degree of improvement of observation group was better than that in the control group， the differences were statistically significant (P<0.05). After treatment， the compliance rates of TC， TG， LDL-C in observation group was significantly higher than that in the control group (P<0.05). There were no serious adverse reactions on liver and kidney in the two groups， the incidence of adverse reactions was not significantly different between the two groups (P>0.05).Conclusion：In treating coronary heart disease， Tongxinluo capsule combined with atorvastatincan significantly reduce the levels of serum TC， TG， LDL-C， improve blood lipids compliance rate， and has a high clinical safety. It is worthy of clinical application and promotion.