The incidence of knee osteoarthritis tends to occur in aging population in China. Among the patients with severe knee osteoarthritis， the elderly occupy the most. For those patients that cannot conduct knee arthroplasty because of their conditions and a variety of other reasons， conservative therapy can achieve certain curative effects. Professor Hu Yinqi advocates that treating TCM rheumatic disease should use syndrome differentiation with disease treatment combined. The etiology and pathogenesis， and development process and treatment of the disease between TCM rheumatology and othopedic disease share some common ground. Through learning the ideas from Professor Hu Yinqi on the combination of disease and syndrome， this study has received certain curative effects on the clinical application in the treatment of severe knee osteoarthritis. The paper is an analytical summary from the following aspects： 1）Syndrome Differentiation and Treatment; 2）the use of medicine and special attention on modern pharmacological research; 3）comprehensive treatment; 4）cases analysis.