To analyze and summarize the clinical manifestation of diabetic peripheral neuropathy (DPN) as well as the medical etiology and to seek for the classic treatment with Chinese herbs for DPN. Methods：The classical DPN etiology was summarized and concluded by referring to the domestic and foreign lecture. Differentiation was carried out for DPN according to the characteristics with corresponding prescriptions of traditional Chinese medicine. Results：According to the syndrome differentiation and treatment of clinical DPN manifestation， as well as the etiology and pathogenesis， the representative drug therapy with effective curative effect through clinical observation over the past years was adopted， and the classical DPN ancient prescription， application of single Chinese herb and hospital preparation were illustrated in details. Conclusion：The pathogenesis of DPN is complicated and changeable. Although hyperglycemia is the initial factor of DPN， its occurrence and development are also related to other factors. In the traditional Chinese medicine， DPN is attributed to the range of ‘diabetes’. According to its clinical manifestation and etiology， the clinical manifestation of DPN can be improved notably through syndrome differentiation and treatment of tonifying qi and yin， warming yang and tonifying kidney， reducing phlegm and removing stasis， promoting blood circulation to remove meridian obstruction.