To observe the effect of Kangfu Xiaoyan Shuan on pelvic inflammatory diseases and immune system. Methods: A total of 60 patients(enrolled from October 2013-October 2014 into our hospital) with chronic pelvic inflammatory diseases were randomly divided into two groups with 30 cases in each. The treatment group received Kangfu Xiaoyan Shuan rectally at bedtime, 1 time / d, 1 dose/ time, for two courses. The control group orally taken Levofloxacin and Ornidazole bivalent, 0.2g / time, 2 times / d, for two courses. Each course lasted 7 days. After two courses, clinical efficacy and T-cell subsets in peripheral blood level changes were observed. Results: The total effective rate of treatment group was 86.7% and control group 76.7%, and the difference between the two groups was statistically significant (P<0.05). After treatment, CD4+, CD4+/ CD8+increased in the control group. While compared with before treatment, the difference was not statistically significant (P>0.05). However, after treatment, CD4+, CD4+/ CD8+increased significantly difference in the treatment group and the difference with before treatment was statistically significant (P<0.05). Compared with before treatment, CD8+levels of both the groups decreased(P<0.05). After treatment, the level differences of CD4+, CD8+, CD4+/ CD8+was statistically significant (P<0.05). Conclusion: Kangfu Xiaoyan Shuan is effective for pelvic inflammatory disease and can significantly improve the patient’s immune function with low incidence of adverse reactions. It is applicable for clinical application.