To observe the clinical effect of regulating and tonifying lung and kidney method on comprehensive prognostic indicators of Chronic Obstructive Pulmonary Disease(COPD) in stable phase. Methods: To select 84 patients with stable COPD in our hospital during 2012 August to 2014 April and randomly divided them into observation group (42 cases) and control group (42 cases). The observation group was given conventional therapy and orally taken regulating and tonifying lung and kidney prescription, while the control group was only given conventional treatment. Then to observe the clinical efficacy and prognosis of the two groups. Results: After treatment, TCM syndrome total score were decreased in both groups, while the observation group was more obvious(P<0.05); Total effective rate of the observation group was 92.86%, significantly higher than than 64.29% in the control group(P<0.05); After treatment, lung function indexes of the two groups were improved, while the indexes of FEV1/ the expected value (%), FVC and FVC/ predicted value (%) and other indicators in the observation groups performed better than the control group (P<0.05); After treatment, the observation group performed better in FEV1/ expected value, respiratory difficulties, 6min walking distance and BODE evaluation score than before (P<0.05). In comparison, after treatment, FEV1/ the expected value, 6min walking distance and BODE evaluation scores in the control group also improved than before(P<0.05), but no obvious improvement in respiratory difficulties were observed(P>0.05); After treatment, FEV1/ the expected value, difficulty in breathing, walking distance of 6min and BODE evaluation total score in the observation group were all better than those in the control group(P<0.05); After treatment the immune indexes, indicators of the quality of life and frequency of acute attack in the observation group was improved in a larger degree than those of the control group(P<0.05). Conclusion: Regulating and tonifying lung and kidney method is effective in the treatment of COPD patients in stable stage, and can improve the prognosis of the patients.