Urethral syndrome, a successive of diseases determined by modern medicine, are commonly seen in married females. Usually, such diseases are hard to treat. Based on different manifestations in clinical, this paper provides 5 treatment patterns of these diseases according to Traditional Chinese Medicine(TCM) theories. The author put forward that the main pathogenesis of these diseases are dampness-heat retention and its pouring downward to bladder, which could also be accompanied by Qi stagnation, blood stasis or Yin deficiency, and thus give rise to disorder of Qi transformation in bladder. For urethral syndrome caused by dampness-heat, dampness is the root and heat is its manifestation, since dampness could lead to heat. To solve this problem, dampness should be removed warmly and heat coolly. Accordingly, the treatment of urethral syndrome should involve both herbs with cold property and warm property. Also, it should avoid excessive use in both herbs, for cold herbs may induce coldness and warm herbs may fuel heat. In summary, to treat these diseases, the four diagnostic techniques should be adopted comprehensively, and appropriate proportion of cold and warm herbs should be given in light of accurate identification of dampness and heat severity.