To investigate the mechanism of catgut implantation at acupoint on simple obesity. Methods:To establish the model of obesity rats by providing high lipid diet. To observe the change of rats’ body weight, body length, Lee ’s index and test the content of serum adiponectin and its receptors after its intervention of catgut embedding therapy. Results: after treatment, the rats of catgut embedding group’s body weight, Lee ’s index were all markedly lower than the control group but still higher than the normal group(P<0.01, P<0.05). Comparison between the weight of male and female catgut embedding group rats before and after treatment shows that male rats weight loss efficacy is superior to female(P<0.01). The levels of serum ADP and AdipoR1 in the control and catgut embedding groups were all markedly lower than that in the normal group(P<0.01), but the level of serum AdipoR2 was higher than normal(P<0.01). After treatment of catgut embedding, the levels of obese rats’ serum ADP and AdipoR1 were rised(P<0.01, P<0.05), while it saw a decrease of AdipoR2(P<0.01). Conclusion: Catgut implantation at acupoint can have benign effect on adiponectin and its receptor levels of obese bodies, and this may be one of the mechanism of catgut embedding therapy of losing weight.