To observe the effects of Qinghou Liyan granules, Yangyin Qingfei syrup and Qinghou Liyan granules combined with Yangyin Qingfei syrup in the treatment of cough in mice caused by ammonia water and sulphur dioxide gas. Methods:Sixty of healthy, clean and male mice were randomly divided into six groups：control group, Yangyin Qingfei Granules group， Qinghou Liyan syrup group, Yangyin Qingfei granule combined with Qinghou Liyan group, Montelukast group and Mixture Glycyrrhiza group. The control group were given water, and the other groups were given drugs. The treatment term lasted for seven days, and drugs were given everyday. Around an hour after giving the drug, mice were placed in YLS-8A device and ammonia water and sulphur dioxide gas were used to induce cough in mice respectively. Recorded were potential cough and the times of cough in three minutes. Results:Compared with the control group, other groups have more obvious effects on extending the incubation period of cough in mice and reducing the times of cough in mice caused by ammonia water and sulfur dioxide gas(P<0.05; Compared with the control group, Yangyin Qingfei syrup group, Gancao mixture group and Montelukast Sodium Tablets group, Qinghouliyan granules combined with Yangyinqingfei syrup group has a better effect on extending the incubation period of cough in mice and reducing the times of cough in mice caused by ammonia water and sulfur dioxide gas(P<0.05; Compared with Qinghou Liyan granules group, Qinghouliyan granules combined with Yangyinqingfei syrup group has a larger effect on extending the incubation period of cough in mice caused by ammonia water and sulfur dioxide gas(P<0.05). Conclusion:Both Qinghou Liyan granules and Yangyin Qingfei syrup have a effect on inhibiting cough. And Qinghou Liyan granules combined with Yangyin Qingfei syrup can enhance the effects of inhibiting cough and extending the incubation period of cough.