Abstract:To optimize extraction process of Radix zanthoxyli. Methods:By using a single factor optimization method, we selected a reasonable extraction process via ethyl alcohol. Optimizing factors are extraction time, number of extractions, extraction solvent, dosage, concentration, PH value; using yield rate and Nitidine Chloride extracted weight as parameters. Results:The optimum extraction process is 80% concentration of ethyl alcohol, extract 2 h each time, extract twice, controlling pH=5 using 0.1 mL/L HCL. Conclusion:The optimized extraction process is suitable for industrial production.