Migraine is a clinical disease whose cause and mechanism have not yet been found out. Traditional Chinese Medicine usually treat it from the perspective of regulating and reinforcing liver, spleen and kidney plus expelling wind and resolving phlegm. Professor Wang Qi found that sometimes migraine is associated with allergic constitution. Thus, he maintained that the treatment of migraine should be started from regulating allergic constitution and coordinated with Three Identified Model of identifying constitution-disease-syndrome. In clinical treatment, Professor Wang Qi adopted Smoked Plum(Wu Mei), Periostracum Cicada(Chan Yi), Radix Polygoni Multiflori (Shou Wu), Ganoderma lucidum (Yesheng Chizhi) combined with Smilax Glabra Roxb (Tu Fu Ling) to regulate patients constitution, and has gained favorable achievements. This article focuses on summarizing Professor Wang Qis view on the cause and mechanism of migraine, and its relation with allergic constitution. Also, two cases of migraine treatment from the therapeutic perspective of Professor Wang Qi were chosen for the reference of readers.