Metabolic syndrome (MS) is a pathological state involved with a variety of metabolic disorders, including glucose metabolism, lipid metabolism disorders, and high blood pressure, which are all resulted from insulin resistance (IR). With rich experience of clinic work, professor Tong Xiaolin regard that the from the aspect of Traditional Chinese Medicine (TCM), the pathogenesis mechanism of obesity, hyperlipidemia, type II diabetes and other subcategories of MS all relate to “ointment turbid”. This means that in the early stage of life, the patient had been eating excessive fat, which obstruct the spleen, and induce obesity. In a longer term, the turbid of ointment transfer to “sugar turbid” “fat turbid” and “uric acid turbid”. Besides, western medicine regard liver as a vital organ in metabolizing sugar and generating insulin resistance. Professor Tong draw a comparison between TCM and western medicine, and concluded that in MS, diabetes involved with fat metabolism or fatty liver were very common, which should be treated from regulating liver and stomach. To differentiate spleen obstruction and liver stagnation and to regulate liver firstly, professor Tong mainly adopted Major Bupleurum Decoction and Virgate Wormwood Decoction. Hopefully, this will provide advice for future treatment.