To investigate the impact of Yishenhuoxue granules on fibrosis of patients with qi deficiency and blood stasis type of early diabetic nephropathy and its effect on CTGF.Methods:90 cases of patients with qi deficiency and blood stasis type of type 2 diabetic nephropathy (DN) were divided into normal group and observation group by using random envelope,45 cases in each group,45 cases of healthy physical examination in the corresponding period as healthy control group,both of the two groups of patients with DN accepted the treatment such as positive control of blood glucose,high blood pressure treatment, adjusted abnormal lipids metabolism,the observation group added Yishenhuoxue granules based on the treatment.Both of the two groups according to 12 weeks for a period of treatment, tested the changes of three sets of albuminuria excretion rate (uAER) and collagen type I,Ⅲ (PI NP,P Ⅲ NP),and connective tissue growth factor (CTGF) of the urine before and after 12 weeks of treatment.Results:1) 24 h before the treatment,urine protein excretion rate,HbAlc,FGC,2 h BG of the two groups of patients were with no statistical differences (P>0.05),24 h after the treatment,urine protein excretion rate,FPG,OGTT of the two groups reduced compared to before the treatment,and the comparison with the conventional group,the observation group reduced the more obvious extent(P<0.05);The clinical effectiveness of observation group was obviously higher than that of control group(P<0.05).2)Compared with before treatment,uAER,collagen type I,Ⅲ and CTGF levels in patients of observation group and conventional therapy group were significantly decreased after 12 weeks(P<0.01),the indexes above of the observation group were significantly lower than that of conventional treatment group(P<0.05).3)After related parameters correlation analysis by using of Spearman method,it showed CTGF and PI NP,P Ⅲ NP had positive correlation (P<0.05).Conclusion:Yishenhuoxue granules can significantly reduce urinary CTGF level,this effect may be one of the mechanism of Yishenhuoxue granules prevent and treat qi deficiency and blood stasis type of early diabetic nephropathy fibrosis.