To establish the optimal extraction technology for compound dendrobium. Methods:To use the content of crude polysaccharide, flavonoids, dendrobine and the extraction rate as indexes and use the method of multiindex comprehensive evaluation and setting of weight coeffficient to choose the best extraction technology by the orthogonal design. Results:The optimum conditions was 10 times of 70% alcohol and water reflux 120min respectively. Conclusion:The optimal extraction is objective, feasible, stable and reliable, which provides experimental basis for industrial production of compound dendrobium.