To analyze the syndrome differentiation and prescription of Li Wenquans cough cases. Methods:Hundreds of Professor Lis cough cases were reviewed according to medical records, and the database and data analysis techniques were adopted to study the syndrome characteristics and the corresponded prescriptions and materia medicas. Results:The most common syndromes were sorted as follows: phlegmdampness, phlegmheat, qi deficiency, yin deficiency, external contraction, blood stasis, qi stagnation and so on. The most common prescriptions were sorted as follows: Decoction of Two Old Ingredients, WhiteDraining Powder, selfmade Quxie Zhenke Formula, ThreeSeed Filial Devotion Decoction and so on. The basic materia medicas were sorted as follows: Pinellia Tuber, Dried Tangerine Peel, White Mulberry RootBark, Baical Skullcap Root, Heartleaf Houttuynia Herb, Hogfennel Root, Bile Arisaema, Thunberg Fritillary Bulb, Apricot Seed and so on. Conclusion:The study reflected Professor Li Wenquans clinic thought in treating cougheliminating pathogen and reinforcing healthy qi. His clinic experience mainly focused on resolving phlegm, clearing heat, and purging lung. With the method of reinforcing healthy qi and tonifying deficiency, yin is nourished. Regulating qi and dredging collaterals helped recover lungs function of dispersion and purification and descent.