To observe the relation between main syndromes of chronic hepatitis B and the occurrence of stool abnormality. Methods: General information of 612 chronic hepatitis B patients from two hospitals in Guangzhou, including the index of the severity of patients, their stool abnormality, symptoms and signs, syndrome differentiation of TCM and other first-hand accounts were collected. Then these were used to statistically analyze the relation between stool (a. diarrhea or thin sloppy stool, b. stool viscosity and stoppage, c. sometimes dry, while sometimes viscous stool, d. normal stool, e. constipation) and chronic hepatitis B, different syndrome types, age, gender and severity of patient’s condition. Results: Among the 612 chronic hepatitis B patients, the incidence of abnormal stools was 70.91%, with the incidence of male abnormal stools being 72.28% and female being 69.12%, there being no statistical significance(P>0.05). There was statistical significance among different age groups(P<0.05). The incidence of abnormal stools of the 41 to 50 and 51 to 65 age groups were 75.52% and 88.27% respectively, which was much higher than that of the 31 to 40 and 18 to 30 age groups. The priority of the incidence of abnormal stools was b, a, e, c. The priority of the five types of syndrome differentiation among the 612 chronic hepatitis B patients was dampness-heat of liver and gallbladder syndrome, liver depression and spleen deficiency syndrome, dampness obstructing spleen-stomach syndrome, yin deficiency of liver and kidney syndrome and hepatic blood stagnation syndrome. Among patients with dampness-heat of liver and gallbladder syndrome, 94.61% of them suffered from stool abnormality and the abnormal rate of type b was the highest, accounting for 54.64%. Among patients with liver depression and spleen deficiency syndrome, 51.75% of them suffered from stool abnormity and the abnormal rate of type a was the highest, amounting to 40.35%. Among the 612 chronic hepatitis B patients, 38 were severe cases, of whom 92.10% suffered from stool abnormality, also the abnormal rate of type a was the highest, accounting for 47.37%; 303 were moderate cases, of whom 98.02% suffered from stool abnormality and the abnormal rate of type b was the highest, accounting for 80.86%; 271 were mild cases, of whom only 37.64% suffered from stool abnormality and the abnormal rate of type b was the highest, amounting to 25.09%. The abnormal rate of severe and moderate patients who suffered from stool abnormality was high, while that of mild patients was relatively low(P<0.05). This may relate to the development of chronic hepatitis B and the drugs influence on gastrointestinal function. Conclusion: Stool abnormality was a common syndrome among chronic hepatitis B patients, especially among middle-old aged patients; stool viscosity and stoppage, diarrhea or thin sloppy stool were the most common abnormal stool, which deserved special concern by clinicians. The dampness-heat of liver and gallbladder syndrome was the most common type among chronic hepatitis B patients in Guangzhou Province with the highest occurrence of stool abnormality. Stool viscosity and stoppage being the most common syndrome. This paper can partially prove that stool viscosity and stoppage is the most common syndrome of damp-heat syndrome for chronic hepatitis B patients in the south of the Five Ridges, which should be the primary symptom of dampness-heat of liver and gallbladder syndrome.